The “War on Drugs” has been a primary driver of mass criminalization, incarceration, and law enforcement violence targeting Black people over the past five decades, devastating families, communities, and generations. Prostitution enforcement has consistently served as a mechanism for profiling, pathologization, targeting, physical and sexual violence, criminalization, and structural exclusion for Black women, trans, and gender nonconforming people, and regulation of sexual and reproductive autonomy. Both the drug war and prostitution enforcement divert millions of dollars away from meeting the needs of people with substance dependence and people in the drug and sex trades, including non-coercive, accessible, and evidence-based treatment, housing, health care, education, and living wage employment.